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Mannich Base

  • Page ID
    40651
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    The acid-catalyzed reaction of an enolizable aldehyde or an enolizable ketone with an imminium ion, usually generated in situ by the reaction of formaldehyde with a secondary amine, followed by a base to give a β-aminoaldehyde of a β-aminoketone, respectively, is known as the Mannich reaction. The product of the Mannich reaction is called the Mannich base.

    eg:

    mannichreaction1.png

    mechanism:

    mannichreaction2.png


    This page titled Mannich Base is shared under a All Rights Reserved (used with permission) license and was authored, remixed, and/or curated by Gamini Gunawardena via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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