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Copyright (c) 2006-2014 MindTouch Inc.
This file and accompanying files are licensed under the MindTouch Master Subscription Agreement (MSA).
At any time, you shall not, directly or indirectly: (i) sublicense, resell, rent, lease, distribute, market, commercialize or otherwise transfer rights or usage to: (a) the Software, (b) any modified version or derivative work of the Software created by you or for you, or (c) MindTouch Open Source (which includes all non-supported versions of MindTouch-developed software), for any purpose including timesharing or service bureau purposes; (ii) remove or alter any copyright, trademark or proprietary notice in the Software; (iii) transfer, use or export the Software in violation of any applicable laws or regulations of any government or governmental agency; (iv) use or run on any of your hardware, or have deployed for use, any production version of MindTouch Open Source; (v) use any of the Support Services, Error corrections, Updates or Upgrades, for the MindTouch Open Source software or for any Server for which Support Services are not then purchased as provided hereunder; or (vi) reverse engineer, decompile or modify any encrypted or encoded portion of the Software.
A complete copy of the MSA is available at http://www.mindtouch.com/msa
Sodium Azide is a colorless, explosive, and highly toxic salt that is soluble in water.
Sodium azide is used as a source of azide anion which is a strong nucleophile that readily displaces suitable leaving groups. Azide functionalized molecules can undergo a number of transformations including copper-catalyzed [2+3] cyclocondensation with terminal alkynes and the Staudinger Reaction. Sodium azide is also commonly used as a preservative in many biochemical solutions.
Sodium azide is explosive and should be handled gently. Care should be taken to avoid grinding crystals trapped in ground glass joints and the threads of jars and bottles. It can also form highly explosive salts with many transition metals. This is of particular concern in one-step reactions involving in situ azide synthesis followed by a Huisgen 1,3-dipolar cycloaddition. Common reagents are both sodium azide and copper, from which highly explosive and shock sensitive copper azides can be produced.
Sodium azide is a potent toxin, possessing toxicity similar to that of cyanide. Like cyanide it functions by tightly binding the iron in heme cofactors. Solutions of sodium azide can be absorbed through the skin and mucous membranes.
The azide ion can react with acids to form the extremely explosive, volatile, and toxic hydrazoic acid. Take care to avoid acidifying mixtures containing sodium azide.
Halogenated solvents such as dichloromethane and chloroform can form extremely explosive di- and triazidomethanes with sodium azide. See this Organic Process Research & Development article for details of a diazidomethane explosion: http://pubs.acs.org/doi/abs/10.1021/op8000977.
Excess azide represents a health and safety hazard and should be quenched before disposal. For a detailed description of how to quench sodium azide see the Health and Safety provided by Northeastern University: http://www.ehs.neu.edu/hazardous_waste/fact_sheets/sodium_azide/. It can be quenched by nitrous acid
2NaNO2 + H2SO4 → 2HNO2 + Na2SO4
2NaN3 + 2HNO2 → 3N2 + 2NO + 2NaOH
This operation should only be carried out in a functioning fume hood using a vessel with a gas outlet
Iodine-starch paper can be used to test for an excess of nitrite which indicates that the quench is complete. Dispose of the solution as you would other aqueous waste.
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